Gene mutations in B cells increase with age
Lymphocyte is a kind of white blood cell. It is the smallest white blood cell and is produced by lymphatic organs, and is an important cellular component of the body's immune response function. Lymphocytes can be divided into T lymphocytes, B lymphocytes and natural killer cells. Some researchers have found that the number of somatic mutations in human B lymphocytes increases with age.
As scientists continue to try to understand the causes of aging in humans and other animals and want to find ways to stop aging, they are beginning to pay attention to the speed at which our cells are mutated. In this new study, the researchers sequenced B lymphocytes from infants up to the age of 100. Their goal was to understand the mutation rate of B lymphocytes as they age.
The researchers reported that they found that the number of gene mutations increased with age. For example, the median genetic mutation in newborns was 463.4. The median was 1,181.9 for those aged 27 to 30, 2101.7 for those aged 52 to 75 and 3127.0 for those aged 97 to 106. They also noted that most of the mutations were specific to the cells of the individuals with those mutations -- although there were some exceptions. For example, they found that about 24 mutations were identical in other cells of the same person. These mutations appear randomly throughout the genome, except in a few hot spots.
The researchers found that some of the mutations they observed were similar to the mutation types of certain cancer cells. They combined sequencing results with data from exome and ATAC sequencing and found that mutations in the transcription factor binding domain also increased with age, as did mutations in the active open chromatin region. Their research provides more key evidence that mutations play an important role in aging and cancer.
With the advancement of pharmaceutical research and development, our DLdevelop is also working hard for this. We focuse on the research and development of Elisa reagents, and has achieved good results. Regarding the B lymphocytes mentioned above, DLdevelop has developed some related kits, such as DL-BLC1-Hu，DL-BLC1-Mu. If you want to know more about it, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-blc1-hu.html
https://dldevelop.com/Research-reagent/dl-blc1-mu.html
As scientists continue to try to understand the causes of aging in humans and other animals and want to find ways to stop aging, they are beginning to pay attention to the speed at which our cells are mutated. In this new study, the researchers sequenced B lymphocytes from infants up to the age of 100. Their goal was to understand the mutation rate of B lymphocytes as they age.
The researchers reported that they found that the number of gene mutations increased with age. For example, the median genetic mutation in newborns was 463.4. The median was 1,181.9 for those aged 27 to 30, 2101.7 for those aged 52 to 75 and 3127.0 for those aged 97 to 106. They also noted that most of the mutations were specific to the cells of the individuals with those mutations -- although there were some exceptions. For example, they found that about 24 mutations were identical in other cells of the same person. These mutations appear randomly throughout the genome, except in a few hot spots.
The researchers found that some of the mutations they observed were similar to the mutation types of certain cancer cells. They combined sequencing results with data from exome and ATAC sequencing and found that mutations in the transcription factor binding domain also increased with age, as did mutations in the active open chromatin region. Their research provides more key evidence that mutations play an important role in aging and cancer.
With the advancement of pharmaceutical research and development, our DLdevelop is also working hard for this. We focuse on the research and development of Elisa reagents, and has achieved good results. Regarding the B lymphocytes mentioned above, DLdevelop has developed some related kits, such as DL-BLC1-Hu，DL-BLC1-Mu. If you want to know more about it, you could contact our professional staff directly or directly to our website:
https://dldevelop.com/Research-reagent/dl-blc1-hu.html
https://dldevelop.com/Research-reagent/dl-blc1-mu.html
